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Thursday, 28 May 2020 14:39

Being a mouse in 2020

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Being a mouse in 2020

Why being a mouse means you could be a guinea pig for humans trying to cure diseases.

Probably lots of mouses are being given Covid 19 these days.

Overall, mice and humans share virtually the same set of genes. Almost every gene found in one species so far has been found in a closely related form in the other.

On average, the protein-coding regions of the mouse and human genomes are 85 percent identical; some genes are 99 percent identical while others are only 60 percent identical.

Human, mouse and other mammals shared a common ancestor approximately 80 million years ago. Therefore the genomes of all mammals are comparably similar. Comparisons of the DNA sequence of the dog or the cow with that of the human theoretically would be quite informative. However, the mouse has a major advantage in that it is a well-established experimental model. Not only can genes easily be found in mouse genome sequence, but it also is possible to test experimentally the function of those genes in the mouse. Thus, scientists can mimic in mice the effect of DNA alterations that occur in human diseases and carefully study the consequences of these DNA misspellings. Mouse models also afford the opportunity to test possible therapeutic agents and evaluate their precise effects.

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